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Certain areas like the area between the eyebrows are at higher risk because of the architectural layout of the blood vessels under the skin.
The incidence of heart attack from injection of a skin filler should be close to zero.
Or the Science Teacher who occasionally poisons her students (and herself)...
The manga was released in English by Vertical in 2016.
An anime adaptation by Kyoto Animation premiered on Japanese television in April 2011.
The series was directed by Tatsuya Ishihara, with Jukki Hanada serving as series composer, Futoshi Nishiya serving as character designer, and Taichi Ishidate serving as co-director.
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But the wrinkle-smoothing wonder that is Botox Cosmetic didn’t just spring forth like Athena leaping from Zeus’ ultra-smooth forehead.
The skin necrosis after dermal filler injection is due to direct injection into an artery or compression of an artery by the filler preventing blood flow.
This is the only reference I could find "The most serious side effect is localized tissue necrosis, which is induced by mechanical interruption of local vascularity, though it occurs very rarely (nine in 10,000 patients who underwent collagen implantation)".
Addendum December 13, 2012: A recent survey of British Association of Aesthetic Plastic Surgeons members found that 69 percent of surgeons reported seeing patients with complications from temporary fillers in the previous 12 months.
49 percent reported seeing patients with complications due to semi- or permanent fillers.
The most import thing besides proper injection technique is that if you experience inappropriate pain after filler injection and/or see significant skin discoloration beyond a little bruising your doctor needs to go into emergency mode.