Seroquel too sedating for bipolar
Course format (distance learning - online activity). Net has been approved by the National Board for Certified Counselors (NBCC) as an Approved Continuing Education Provider (ACEP), ACEP #6323. Social workers should contact their regulatory board to determine course approval.Here’s the thing: if one molecule of Seroquel goes to H1, and not to D2, then can it have any antipsychotic effect? One molecule binds to H1, so it isn't an antipsychotic, it's an antihistamine. The drug can't be called an antipsychotic unless it is behaving as an antipsychotic, regardless of the product labeling.ARE YOU SAYING THE FDA ARE A BUNCH OF UNSCIENTIFIC ASS-MONKEYS? At some amount of D2 blockade, these things will be antipsychotics. Theories abound, but look at it this way: 10mg of Zyprexa blocks a certain number of D2 receptors.
Which brings us to the third problem: if you do try and change your perspective, get out and measure those lines, you will be quickly dispatched by a minivan to the face for your lack of faith.
So, here, Seroquel is very antihistaminergic—so it causes a lot of sedation. Think how sedating 25mg of Seroquel is (trust me, it's sedating.) Why isn't 32 times more-- 800mg-- lethal?
It is moderately an alpha1 blocker—which is what causes orthostasis (lightheadedness/dizziness/grogginess). It has to "choose." And most likely it chooses to go to H1. Certainly 32mg of Xanax is more than a short nap, so what's the difference?
500mg is an antipsychotic; 100mg is not an antipsychotic.
I know it looks like it’s five times more, but it’s not—it’s the addition of a completely new level. Reducing these doses by half pretty much extinguishes the D2 blockade.
All this notwithstanding, they are still usefully inaccurate. everywhere else.) Note that binding is related to the rates of the binding (Kd=Koff/kon) If you want a real world example, look at Zyprexa, below-- a real human in a real PET scanner eating real Zyprexa: If you increase the dose from 5mg to 30mg, serotonin binding increases from 95% to 100%.